Journal article
Post-streptococcal glomerulonephritis is a strong risk factor for chronic kidney disease in later life
WE Hoy, AV White, A Dowling, SK Sharma, H Bloomfield, BT Tipiloura, CE Swanson, JD Mathews, DA McCredie
Kidney International | NATURE PUBLISHING GROUP | Published : 2012
DOI: 10.1038/ki.2011.478
Abstract
Although unusual in western countries and in Australia in general, post-streptococcal glomerulonephritis (PSGN) is still common in Australian Aboriginal children living in remote communities. Here, we evaluated whether episodes of acute PSGN increased the risk for chronic kidney disease in later life in 1519 residents of a remote Aboriginal community (85% of those age eligible), with high rates of renal and cardiovascular disease, who participated in a health screen over a 3-year period. Of these, 200 had had at least one episode of PSGN, with 27 having had multiple episodes, usually in childhood. High levels of albuminuria (albumin/creatinine ratio) with increasing age were confirmed. All P..
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Awarded by Amgen
Funding Acknowledgements
Much of this work was done with or through the Menzies School of Health Research (MSHR) in Darwin, NT. JDM, WEH, DAM, AVW, SKS, and HB have been affiliated with MSHR. Other MSHR staff members have been involved in many aspects of this project, including Mrs Susan Hutton and Mrs Jo Bex, in the scientific laboratories. This study was supported by the National Health and Medical Research Council of Australia, through projects Grant # 951134, Senior Fellowship Grant, # 951342, Program Grant # 320860, and Australia Fellowship award # 551081. It was also supported by long-term funding from Kidney Health Australia, from 11 years of funding from the Colonial Foundation of Australia, and grants from Amgen, Australia. The work could not have been conducted without the ongoing support of the Tiwi Land Council. We thank all the Tiwi project staff, including Richard Tungatalum, Flora Tipungwuti, Danielle Munkara, Aileen Tiparui, Ian Alimankinni, and Eric Tipiloura, as well as the staff at the health clinics on the Tiwi Islands. The medical records from which the histories were retrieved had been maintained up until the early 1990s by the Sisters of Our Lady of the Sacred Heart, most recently under supervision of Sister Maureen Carey, to whom we are greatly indebted.